opendose_poppk.PopulationSimulator

class opendose_poppk.PopulationSimulator(pk: PKModel | None = None, pd: PDModel | None = None, covariate_model: CovariateModel | None = None, dose: float = 1000.0)

Monte Carlo simulation of heterogeneous population with covariates.

Integrates PKModel + PDModel + CovariateModel to generate individual PK/PD profiles with realistic covariate distributions.

Example

>>> pk  = PKModel(F=0.8, ka=1.8, ke=0.28, Vd=65)
>>> pd  = PDModel(EC50=10.0, n=1.5)
>>> sim = PopulationSimulator(pk, pd, dose=1000.0)
>>> res = sim.run(n_subjects=1000, t_max=12.0,
...               covariates={"weight": ("normal", 70, 15),
...                           "crcl":   ("normal", 90, 30)})

__init__(pk: PKModel | None = None, pd: PDModel | None = None, covariate_model: CovariateModel | None = None, dose: float = 1000.0)

Methods

__init__([pk, pd, covariate_model, dose])
run([n_subjects, t_max, n_points, ...])	Execute Monte Carlo simulation.
simulate([n])	Legacy compatibility method: returns list of profiles.