Changelog

All notable changes to this project are documented here. Format follows Keep a Changelog. Versioning follows Semantic Versioning.

PKModel: 1-compartment analytical model with optional 2-compartment ODE mode and radioactive decay.
PDModel: Emax Hill pharmacodynamic model.
DrugDatabase: CSV-backed drug parameter loader.
CovariateModel: Power-model covariate adjustment (weight, CrCl, age, hepatic markers).
PopulationSimulator: Monte Carlo population simulation with 90 % prediction intervals.
MAPEstimator: Bayesian Maximum-A-Posteriori individual parameter estimation.
Full test suite (pytest) with 90 %+ coverage.
Sphinx documentation with RTD theme, autodoc, Napoleon, nbsphinx.
GitHub Actions CI for tests and documentation build.
Demo notebook (notebooks/demo_paracetamol.ipynb).
Companion paper draft (paper/paper.md).