Changelog

Changelog

All notable changes to this project are documented here. Format follows Keep a Changelog. Versioning follows Semantic Versioning.

[1.0.0] – 2024-12-01

Added

  • PKModel: 1-compartment analytical model with optional 2-compartment ODE mode and radioactive decay.

  • PDModel: Emax Hill pharmacodynamic model.

  • DrugDatabase: CSV-backed drug parameter loader.

  • CovariateModel: Power-model covariate adjustment (weight, CrCl, age, hepatic markers).

  • PopulationSimulator: Monte Carlo population simulation with 90 % prediction intervals.

  • MAPEstimator: Bayesian Maximum-A-Posteriori individual parameter estimation.

  • Full test suite (pytest) with 90 %+ coverage.

  • Sphinx documentation with RTD theme, autodoc, Napoleon, nbsphinx.

  • GitHub Actions CI for tests and documentation build.

  • Demo notebook (notebooks/demo_paracetamol.ipynb).

  • Companion paper draft (paper/paper.md).

[Unreleased]

  • PyPI publication.

  • ReadTheDocs integration.

  • Additional drug entries in datasets/drugs_parameters.csv.